Urea cream is primarily used to treat a variety of skin conditions characterized by dryness, roughness, scaling, or thickening of the skin[1][2][4]. It is especially effective in managing:
- Dry skin and rough skin[1][4]
- Dermatitis (including atopic and contact dermatitis)[1][2][4]
- Psoriasis[1][2][5]
- Ichthyosis (a condition leading to scaly skin)[1][2][4]
- Eczema (including hand eczema)[1][2][5]
- Keratoderma (thickening of skin on soles and palms)[1][2][6]
- Corns and calluses[1][2][4][6]
- Keratosis pilaris (small hard bumps on the skin)[4][6]
- Radiation dermatitis and seborrheic dermatitis[4][5]
- Damaged, ingrown, and devitalized nails[1][2][6]
Urea cream is widely available over the counter and has been used since the 1940s. It is considered essential by the World Health Organization for basic healthcare due to its safety, effectiveness, and affordability[1][4].
In addition to moisturizing effects, urea creams can facilitate gentle exfoliation (especially at concentrations above 20%), helping soften and shed thickened or scaly skin areas[1][3]. It also promotes healing in skin with hyperkeratosis or necrotic tissue and is sometimes indicated if infection or debris is present[1][2].
Clinical studies support benefits for elderly patients with xerosis (age-related dry skin) and diabetic foot care, where urea creams improve skin hydration and help prevent infection or ulceration[3].
Common side effects include mild skin irritation, burning, stinging, or itching; more severe reactions, like allergic rashes or swelling, are rare but possible[1][4][6]. Urea creams are generally safe for adults but may not be recommended for children under 2 years old without doctor guidance[4].
References
- [1] Urea-containing cream – Wikipedia
- [2] Urea: Uses, Interactions, Mechanism of Action | DrugBank Online
- [3] Urea in Dermatology: A Review of its Emollient, Moisturizing …
- [4] Urea in Lotion and Cream: Benefits, Side Effects, How to Use It
- [5] The Use of Urea Cream for Hand Eczema and Urea Foam for …
- [6] Urea topical: Uses, Side Effects, Interactions, Pictures … – WebMD
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